English name: Nifedipine
2-nitrophenyl-3,5-pyridinedicarboxylicaciddime; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4- (2-nitrophenyl) -2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaearedimethy; 5-pyridinedicarboxylicacid, 1,4-dihydro-2,6 -dimethyl-4- (2-nitrophenyl) -dim; Adalat CC; bay1040; corinfar; Dimethyl 1,4-dihydro-2,6-dimethyl-4- (o-nitrophenyl) -3,5-pyridinedicarboxylate
CAS Number: 21829-25-4
Molecular formula: C17H18N2O6
Molecular weight: 346.34
EINECS number: 244-598-3
Chemical properties Yellow crystals. Melting point 172-174 ° C. Soluble in acetone, chloroform, ethyl acetate, soluble in hot methanol, insoluble in water. Met light easily metamorphosed.
Quality standard: CP / USP
Packing: 25KG cardboard drum
Price: 168.5 / KG above 25KG
Long-term use of coronary artery dilatation drugs. This product can increase coronary blood flow, reduce myocardial oxygen consumption. For acute and chronic coronary insufficiency, into it is myocardial infarction and myocardial infarction.
Pharmacological effects Nifedipine also known as nifedipine, nicotine, nifedipine, is a dihydropyridine calcium antagonist, can inhibit myocardial and vascular smooth muscle Ca2 + uptake, expansion of coronary artery, increased coronary blood flow, increased Myocardial tolerance to ischemia, while expanding the surrounding arteries, reduce peripheral vascular resistance, relieve coronary artery spasm, increase coronary flow, improve myocardial hypoxia, so that blood pressure. Small doses of coronary artery do not affect blood pressure, for better anti-angina drugs. For the prevention and treatment of coronary heart disease angina, no adverse effects on respiratory function, especially for coronary artery spasm caused by angina and airway obstruction with angina pectoris best, its effect is better than β-blockers. Also applies to all types of hypertension, including severe and refractory hypertension. Treatment of refractory congestive heart failure can take long-term use of this product. Also for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcer, urethral obstruction, exercise asthma, achalasia and so on.
Nifedipine on the vascular smooth muscle with a certain selectivity, the role of the heart directly negative muscle strength and degeneration is weak, so systemic administration does not cause heart rate slowed down and showed increased heart rate reflex
